Sr. Associate Scientist, Upstream Process Development
Job Description
What You Will Achieve
A Senior Associate Scientist (R2) position is available in the Upstream Process Development group within the Bioprocess R&D organization. The successful applicant will join a team of scientists and engineers focused on developing and optimizing manufacturing processes for recombinant proteins and mRNAs for early- and late-phase human clinical trials. In this role, the candidate will be responsible for designing and executing laboratory experiments in bench-top bioreactors and associated scale-down equipment with the goal of developing robust, scalable, and high productivity processes. The work will also involve working with pilot, clinical, and commercial production facilities to ensure accurate technology transfer, successful large-scale production and associated regulatory filing activities. The candidate may also be involved in cutting edge technology development projects that seek to improve production processes and control strategies leveraging various process analytical technologies.
How You Will Achieve It
- Design and execute experiments in appropriate scale-down models such as shake flasks and bioreactors in an effort to develop robust, high yield, and scalable manufacturing processes
- Serve as upstream tech lead; ensure accurate tech transfer to pilot and GMP manufacturing facilities; provide technical support during manufacturing campaign
- Timely and accurately document data in electronic lab notebooks; author technical reports and contribute to relevant sections of regulatory submissions such as IND and BLA
- Participate and contribute to discussions in lab and project team meetings on design of experiments and interpretation of data
- Contribute to safe, efficient, and harmonious lab environment; strong lab citizen and collaborative team player
- Occasionally work over the weekend to passage flasks, sample bioreactors or perform other essential tasks
QUALIFICATIONS
Must Have
- Bachelor’s degree with 3-5 years’ industrial experience or Master’s degree with 0-3 years industrial experience in Chemical/Biochemical Engineering, Biotechnology, Microbiology or a relevant field.
- Significant experience with sophisticated lab instruments such as bioreactor systems and analytical equipment.
- Strong mammalian cell culture expertise required.
- Self-motivated, organized, and excellent attention to details.
- Excellent oral and written communication skills.
- Ability to adapt in a fast-paced environment with shifting priorities.
Nice To Have
- Experience with high-throughput instrument such as ambr15, ambr250, and Tecan liquidhandler
- Knowledge pertaining to in vitro transcription for mRNA synthesis or hands-on experience with molecular biology techniques.
- Experience with developing and implementing process analytical technologies such as Raman spectroscopy and biocapacitance.
- Proficiency with multi-variate data analysis techniques
PHYSICAL/MENTAL REQUIREMENTS
- Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
- May require occasional work on the weekend for essential tasks
- May need to travel occasionally to attend internal meetings or external conferences
Other Job Details
Work Location Assignment: On Premise
The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
