Postdoctoral Fellow, ADC Chemical Biology
Pfizer Inc.
Washington – Bothell, NY
Job posting number: #7288165 (Ref:pf-4920361)
Posted: October 27, 2024
Job Description
What you will achieve:
Targeted drug delivery is finding increasing application in the pharmaceutical field, highlighted by the impact that Antibody Drug Conjugates have made in the oncology space. Pfizer Oncology R&D is seeking a postdoctoral fellow to work within the ADC Chemistry team to characterize a unique natural delivery pathway and develop potential applications for therapeutic use. This is an exciting postdoctoral opportunity at the chemistry–biology interface which will allow the fellow to work with multiple discipline teams while gaining broader drug development insights across the Pfizer organization. The expectation is that this work will lead to publications in top tier journals, setting the foundation for a career in industry or academia.
How You Will Achieve It
Successful candidates will be expected to:
Participate in the design and execution of experiments to identify key cellular processes and proteins required for drug delivery.
Design, synthesize, and test proof-of-concept molecules that leverage the pathway to deliver molecules with therapeutic potential.
Apply working knowledge of synthetic chemistry and basic cell biology to efficiently execute experimental plans.
Organize, interpret, and analyze data, and identify areas where key knowledge is lacking.
Proactively seek out new information and experimental approaches in the literature and incorporate this into the scientific hypotheses and experimental plans.
Effectively communicate data and results at internal and external meetings/conferences.
Produce high impact publications in peer reviewed journals.
Qualifications
Must-Have
Recent Ph.D. in chemical biology, medicinal chemistry, cell biology, or a related field.
Successful record of scientific accomplishments evidenced by scientific publications and/or presentations with at least one first-author publication in a peer-reviewed journal
Willingness to make a minimum 2-year commitment
No more than 2 years of post-degree experience.
Experience in the design, synthesis and application of chemical probes for the interrogation or modulation of biological systems.
Experience with cell biology techniques such as cell culture, plate-based assays, and measurements of DNA/RNA/protein.
Familiarity with genetic perturbation methods such as CRISPR or RNAi.
Demonstrated ability to work effectively independently and as part of a multidisciplinary team.
Ability to learn new technical and analytical skills as needed to achieve experimental aims.
Excellent oral/written communication and organizational skills.
Nice-to-Have
Background in cancer biology is preferred.
OTHER JOB DETAILS
Must have work authorization in the US.
Work Location Assignment:On Premise.On Premise colleagues work in a Pfizer site because it’s needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
