Research Technician II
Baylor College of Medicine
Houston, TX
Job posting number: #7284357 (Ref:20623-en_US)
Posted: September 29, 2024
Job Description
Summary
The Erwin Lab investigates the functional role of repetitive DNA with a focus on translating these discoveries into new diagnostics and therapies for human health. The research vision is based on two discoveries. First, develop a new class of synthetic transcriptional regulators that target repetitive DNA sequences with high affinity and specificity (Erwin et al, Science 2017). The resulting patents were licensed by a startup company who initiated a Phase 1 clinical trial for patients with Friedreich’s ataxia earlier this year. Second, uncovered the recurrent repeat expansions represent an overlooked source of genetic variation in cancer (Erwin et al, Nature, 2023). The Erwin Lab is building on these discoveries with the development and application of tools in genomics, molecular biology, and chemical biology. The goal is to uncover the functions of repetitive DNA, the final frontier of the genome.
The research technician will be responsible for helping to manage the lab and carrying out experiments related to lab project which explores genetic variation in human cancer genomes. This role would be ideal for someone with experience in chemical biology and synthesis, as well as an interest in studying the effects of those molecules in cells.
Job Duties
- Performs the routine elements of research work that requires the use of skills, technical and academic knowledge to follow established procedures and record results.
- Works on solid-phase synthesis of programmable DNA binders (pyrrole-imidazole polyamides).
- Conducts chemical conjugation to make polyamide conjugates.
- Performs mammalian cell culture to grow human cancer cell lines.
- Collects and compiles relevant genomic data.
- Documents results of experiments.
- Orders laboratory supplies and equipment.
- Performs other job-related duties as assigned.
Minimum Qualifications
- Bachelor's degree in a Basic Science or related field. Four years of related experience may substitute for degree requirement.
- No experience required.
Preferred Qualifications
- Experience with chemistry (solid-phase synthesis a plus) may substitute for degree requirement.
- Experience in chemical biology and synthesis.
- Be comfortable synthesizing and characterizing molecules.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.
