Postdoctoral Fellow

The University of Oklahoma Health Sciences Center

Oklahoma City, OK

Job posting number: #7109440

Posted: August 31, 2022

Application Deadline: October 1, 2022

Job Description

A postdoctoral position is immediately available in the Yue laboratory in the Department of Pharmaceutical Sciences, College of Pharmacy at the University of Oklahoma Health Sciences Center. The Yue laboratory is seeking a highly motivated postdoctoral fellow to conduct NIH-funded projects on drug transport proteins. The postdoctoral fellow will study the role and regulation of organic anion transport polypeptide (OATP1B1) and OATP1B3 in drug disposition, aiming to mitigate transporter-mediated drug-drug and drug-disease interactions. Drug transport protein-related research has grown exponentially in the past decade driven by the emergence of the Food and Drug Administration (FDA) Critical Path Initiative and subsequent white papers (Nat Rev Drug Discovery, 2010, 9: 215; Clin Pharmacol Ther, 2018, 104:890; Clin Pharmacol Ther, 2022, 112: 461) and the guidance for industry from the US FDA (https://www.fda.gov/media/134582/download). Multi-disciplinary approaches are utilized in the Yue research program. These approaches include 1) sandwich-cultured primary human hepatocytes; 2) gene-knockout models; 3) proteomics; 4) molecular and cell biology approaches, including confocal microscopy; 5) pharmacogenomics studies; and 6) physiologically-based pharmacokinetic (PBPK) modeling and simulation. For more information, visit https://sites.google.com/view/yuelab

Successful candidates should have a Ph.D. in Cell Biology, Molecular Biology, Pharmaceutical Sciences, Pharmacology, Biochemistry, Immunology, or a related field. Preference will be given to applicants with at least one first-author publication in a reputable journal. Required qualifications are Ph.D., M.D., or Ph.D./M.D. Experience in mammalian cell culture, aseptic technique, and standard cell and molecular biology techniques, including DNA/RNA extraction and immunoblot, are required. Experience with real-time RT-PCR is preferred, but not required. Individuals with experience in protein post-translational modifications and epigenetics are particularly encouraged to apply. Competitive candidates are expected to have excellent oral and written communication skills. Review of applications will begin immediately and the position will remain open until filled. To apply, please send the following materials: a cover letter containing a brief summary of the applicant’s current research, research interests, and career goals; curriculum vitae/resume; contact information for three references to Dr. Wei Yue ([email protected]).
Wei Yue, Ph.D.
Associate Professor
Department of Pharmaceutical Sciences
College of Pharmacy
The University of Oklahoma Health Sciences Center
1110 N. Stonewall Avenue, Suite 328
Oklahoma City, OK 73117
Office: (405) 271-6593 Ext 47828
Email: [email protected]
https://sites.google.com/view/yuelab

OUHSC is one of only four comprehensive academic health centers in the nation with seven health professional schools, providing a broad base of expertise for comprehensive clinical and basic science research, interdisciplinary interaction, and career development. Oklahoma City is a large metropolis with western charm, easy local transportation, vibrant downtown, and excellent suburbs. The University of Oklahoma Health Sciences Center is an Equal Opportunity/Affirmative Action employer that is strongly and actively committed to diversity within its community.




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