Bioinformatician

Harvard Medical School

Boston, MA

Job posting number: #7077036

Posted: April 13, 2021

Application Deadline: Open Until Filled

Job Description

Job-Specific Responsibilities

We are forming a team in the Harvard Medical School Department of Neurobiology dedicated to repurposing natural mechanisms of gene regulation to engineer precision viral vectors for gene therapy. First-generation gene therapy vectors lack optimal regulatory elements that lead to sub-therapeutic levels of expression and off-target toxicity. Our goal is to employ our in-house single-cell screening platform (PESCA, Hrvatin, et al., 2019), to sift through the mammalian genome and identify regulatory elements capable of driving optimal patterns of viral transgene expression to address a wide range of diseases. We are building a technology platform that fills a critical void in the gene therapy space. Our collective mission is to employ these regulatory elements to create novel viral vectors that unlock new indications and set a new standard in gene therapy. We have ambitions to spin off our work into a company to achieve this mission. We are recruiting a full-time Bioinformatician to join our team. This is an outstanding opportunity to play an integral role in building a state-of-the-art database of gene regulatory elements as a foundation of our platform. We are seeking driven and curious individuals with experience in applying bioinformatics to genomic datasets (e.g., scRNA-seq, ATAC-seq, ChIP-seq). Success will likely lead to the licensing of these programs into a new company, with potential future career opportunities.

Basic Qualifications

Bachelor's degree and 3 or more years of relevant experience. Graduate degree in a relevant biological or data analytic field preferred may count towards experience.

Additional Qualifications and Skills

3+ years of academic and/or industry experience analyzing genomic datasets (e.g., single-cell or bulk RNA-seq, ATAC-seq, ChIP-seq). Demonstrated knowledge of best practices in building data infrastructure. Strong communication skills. Ability to meet timelines and deliverables in a fast-paced, collaborative environment. Deep passion for science and for the promise of gene therapy as a therapeutic modality.


Additional Information

This is a 12-month term appointment with the possibility of renewal contingent on funding.

We are committed to cultivating an inclusive workplace culture of faculty, staff, and students with diverse backgrounds, styles, abilities, and motivations. We appreciate and leverage the capabilities, insights, and ideas of all individuals. Harvard Medical School Mission and Community Values

Harvard University offers an outstanding benefits package including:
Time Off: 3 - 4 weeks paid vacation, paid holiday break, 12 paid sick days, 12.5 paid holidays, and 3 paid personal days per year.
Medical/Dental/Vision: We offer a variety of excellent medical plans, dental & vision plans, all coverage begins as of your start date.
Retirement: University-funded retirement plan with full vesting after 3 years of service.
Tuition Assistance Program: Competitive tuition assistance program, incredibly affordable classes directly at the Harvard Extension School, and discounted options through participating Harvard grad schools.
Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
Wellness options: Harvard offers programs and classes at little or no cost, including stress management, massages, nutrition, meditation, and complementary health services.
Harvard access to athletic facilities, libraries, campus events, and many discounts throughout metro Boston.
The Harvard Medical School is not able to provide visa sponsorship for this position.

Harvard Medical School strives to cultivate an environment that promotes inclusiveness and collaboration among students, faculty and staff and to create new avenues for discussion that will advance our shared mission to improve the health of people throughout the world.


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